"I am a 30+ year medicinal herbalist. The presence of pyrrolizidine alkaloids in Boneset (Eupatorium perfoliatum) can be of concern in long-term applications. Late Boneset may be considered a safer option for extended use due to lower levels of these alkaloids. I personally use Hyssop Leafed Boneset (Eupatorium hyssopifolium) and Late Boneset (Eupatorium serotinum) to treat Chronic EBV/viral symptoms for a week at a time. Both are too bitter to drink as a tea (although I have done so) so I tincture mine. All of the bonesets can be used similarly per the scientific and traditional use research I have done. Tip for anyone who cares: It is very helpful to seek out and compare the chemical profiles of plants in the same genus when researching species to see if they can be used similarly. I am not a medical doctor, so I encourage each of you to do your own research and be your own health-care provider. Happy herbaling and God bless!" -Mama Asbell